By S. Nassir Ghaemi

ISBN-10: 052170958X

ISBN-13: 9780521709583

Obtainable and clinically correct, A Clinician's consultant to stats and Epidemiology in psychological healthiness describes statistical options in undeniable English with minimum mathematical content material, making it excellent for the busy health care professional. utilizing transparent language in favour of complicated terminology, boundaries of statistical suggestions are emphasised, in addition to the significance of interpretation - in place of 'number-crunching' - in research. Uniquely for a textual content of this sort, there's vast assurance of causation and the conceptual, philosophical and political elements concerned, with forthright dialogue of the pharmaceutical industry's function in psychiatric learn. by means of making a higher knowing of the area of analysis, this booklet empowers future health pros to make their very own judgments on which records to think - and why.

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Additional info for A Clinician's Guide to Statistics and Epidemiology in Mental Health: Measuring Truth and Uncertainty

Example text

This is obviously the ideal situation; RCTs can be invalid, or less valid, due to multiple other design factors outside of randomization (see Chapter 8). But, if all other aspects of an RCT are well-designed, the impact of randomization is that it can provide something as close to absolute truth as is possible in the world of medical science. Measuring success of randomization All these claims are contingent on the RCT being well-designed. And the first matter of importance is that the randomization needs to be “successful,” by which we mean that as best as we can tell, the two groups are in fact equal on almost all variables that we can measure.

Absolute effect sizes are amounts, such as the difference between drug and placebo on a mood rating scale. If drug leads to 5 points more improvement on the rating scale than placebo, 29 Section 2: Bias then the absolute effect size between the two treatments is 5. Effect size can also be relative. If 80% of those on drug improved markedly versus 20% of those on placebo, then the relative effect size is 80/20 = 4. This is often called the risk ratio, a type of relative risk. Another kind of relative risk is the odds ratio, which is another way of expressing the risk ratio.

This is the standard history, and it is correct in the sense that Fisher and Hill were clearly the first to formally develop the concept Section 2: Bias of randomization and to recognize its conceptual importance for statistics and science. But there is a hidden history, one that is directly relevant to the mental health professions. As a historical matter, the first application of randomization in any scientific study appears to have been published by the American philosopher and physicist Charles Sanders Peirce in the late 1860s (Stigler, 1986).

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A Clinician's Guide to Statistics and Epidemiology in Mental Health: Measuring Truth and Uncertainty by S. Nassir Ghaemi


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