By Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler

ISBN-10: 1849731268

ISBN-13: 9781849731263

Money owed in Drug Discovery describes contemporary case reviews in medicinal chemistry with a selected emphasis on how the inevitable difficulties that come up in the course of any venture may be surmounted or triumph over. The Editors hide a variety of healing parts and medicinal chemistry options, together with lead optimization ranging from excessive throughput screening "hits" in addition to rational, structure-based layout. The chapters comprise "follow-ons" and "next new release" compounds that target to enhance upon first new release brokers. This quantity surveys the variety of demanding situations typically confronted by way of medicinal chemistry researchers, together with the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, together with facts of proposal within the sanatorium for novel organic objectives. The case reports contain medicinal chemistry tales on lately licensed and advertised medicinal drugs, but additionally chronicle "near-misses", i.e., exemplary compounds that could have proceeded good into the hospital yet for varied purposes didn't bring about a winning registration. because the overwhelming majority of initiatives fail ahead of registration, a lot could be discovered from such narratives. by way of sharing a variety of drug discovery reviews and knowledge around the group of medicinal chemists in either and academia, we think that those bills will supply insights into the paintings of medicinal chemistry because it is at present practiced and should aid to serve the wishes of energetic medicinal chemists.

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Accounts in Drug Discovery: Case Studies in Medicinal Chemistry (RSC Drug Discovery Series, Volume 4) by Joel C. Barrish, Percy H. Carter, Peter T. W. Cheng, Robert Zahler


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