By David Nutt, Liam Nestor

A part of the Oxford Psychiatry Library sequence, this pocketbook is a transparent and finished evaluation of the mind technological know-how underpinning dependancy and the way this is helping clarify the present and destiny therapeutics for the variety of addictions, utilizing complete color photographs to augment figuring out. Addiction makes a speciality of the character of dependancy as a mind sickness that features a variety of alternative behavioural characteristics comparable to impulsivity and present dependence, and discusses the severe function of kinetic and pharmacological components. The textual content explains how the first pharmacological pursuits of gear of abuse are actually understood, the relation to the variable nature of dependancy to diverse components, and the way this can bring about new ways to remedy.

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Extra resources for Addiction (Oxford Psychiatry Library)

Example text

5 Burden of disease attributable to alcohol is higher in men. Alcohol-attributable burden of disease in disability-adjusted life-years (DALYs) as a proportion of all DALYs by sex and WHO region in 2004. AFR=African region. AMR=American region. EMR=eastern Mediterranean region. EUR=European region. SEAR=South East Asian region. WPR=western Pacific region. , et al. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders, 2223–2233. Copyright (2009), with permission from Elsevier.

The dorsolateral prefrontal cortex (DLPFC) is located in the lateral, upper, and anterior portions of the cerebrum. e. working memory). This area is also involved in response inhibition, verbal fluency, set shifting, planning, organizational skills, reasoning, and problem-solving. The DLPFC receives dopamine projections from the midbrain VTA via the mesocortical pathway. e. slow) signalling through the D1R. The anterior cingulate gyrus (ACG) is a midline region of the brain located around the anterior portion of the corpus callosum.

Alcohol, stimulants) are highly rewarding. They are rewarding because they induce a conscious experience of pleasure. This pleasure leads to ‘liking’ (see Chapter 3). Pre-clinical research has shown that there are discrete hedonic ‘hot spots’ for this ‘liking’. Specifically, a region within the outer (shell) portion of the NAcc and a region within the posterior VP elicit ‘liking’ responses. g. cocaine, D1R/D2R receptor agonists) more into the shell of the NAcc than the core. Opioid, endocannabinoid, and GABA-benzodiazepine neurotransmitter systems also appear to be important for generating many pleasurable, ‘liking’ reactions to rewards.

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Addiction (Oxford Psychiatry Library) by David Nutt, Liam Nestor


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