By Frank J. Dixon (Ed.)

ISBN-10: 0120224593

ISBN-13: 9780120224593

With contributions from Steven A. Porcelli and different across the world well-known leaders within the box, this quantity keeps the culture of fundamental stories. Papers at the CD1 relatives, confident choice of thymocytes, and molecular and mobile features of XLA spotlight the newest quantity.

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Extra resources for Advances in Immunology, Vol. 59

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1994). This is surprising in view of the fact that these mAbs were originally produced by rats and could possibly reflect the existence of allelic differences between the different rat strains examined. , 1991), suggesting that they must recognize a highly conserved CDld epitope. The serologic definition of CD1 antigens in other species has received relatively little attention. One monoclonal antibody, 5E2, raised against thymocytes from new Zealand White rabbits was extensively characterized and found to recognize a protein designated R-Ta with features analogous to human group 1 CD1 (Wang et al, 1987).

Residues that match the CDl consensus sequence are shaded and boxed. , 1987). Double horizontal lines beneath the a3 domain sequences indicate an area in MHC class I molecules involved in the interaction with CD8. See text for references for individual sequences. Numbers at the start of each line indicate the position of the first residue in the full-length polypeptide (including leader sequence), except for the CD1 consensus sequence for which the number 1 indicates the first residue in each domain.

The importance of P2-microglobulin to the structure and function of MHC class I and other p2-microglobulin-associatedproteins is still not entirely clear. , 1990). A requirement for p2-microglobulin association for efficient surface expression is presumed to exist for CD1 heavy chains as well, although this has not yet been formally analyzed for most CD1 proteins. , the human CD l d protein, as described in detail below, P2- 48 STEVEN A. , 1994). , 1986). , 1991). The demonstration of /32-microglobulin association with CDla heavy chains was initially complicated by conflicting results, although subsequent studies have entirely resolved the resulting controversy and confusion.

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