By Michael Balls, Roy M. Harrison, Ronald E. Hester

ISBN-10: 0854042113

ISBN-13: 9780854042111

Animal experimentation has lengthy been a debatable factor, with impassioned arguments on each side of the controversy. more and more it has develop into extra expedient and possible to strengthen new tools that stay away from using animals. there's contract on each side that aid and refinement of experiments on animals could be an incredible objective for the industries involved.Alternatives to Animal checking out, written via top specialists within the box, discusses the problems concerned and methods that may be taken. themes comprise: the protection overview of chemical compounds; overseas validation and obstacles to the validation of different exams; in vitro trying out for endocrine disruptors; clever techniques to protection review of chemical substances; substitute exams and the regulatory framework.The booklet presents an updated dialogue of the present country of improvement of possible choices to animal trying out and is perfect for execs and lecturers within the box. it will even be of use for graduate scholars wishing to pursue a occupation within the pharmaceutical and cosmetics industries.

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48 have proposed a strategy for the testing of chemicals. They suggest that there should be much more use of exposure (or tonnage)-driven testing and use of non-animal methods in an integrated testing scheme. They also indicate that such schemes can be developed. The option of reducing testing in animals and using exposure information, structure–activity relationships, toxicogenomics and early biomarkers in humans in place of animal testing is clearly more applicable to existing substances and needs to be examined closely.

References 1. Directive 67/548/EEC. 2. Originally the ‘sixth amendment’ directive, Directive 79/831/EEC; now the ‘seventh amendment’ Directive, Directive 92/32/EEC. 3. Originally SI 1982/1496, re-enacted as SI 1993/3050. 4. Directive 92/32/EEC. 5. Technical Guidance Document on Risk Assessment in support of Commission Directive 93/667/EEC on Risk Assessment for New Notified Substances, Commission regulation (EC) no 1488/94 on Risk Assessment for Existing Substances Directive 98/8/EC of the European Parliament and of Council concerning the placement of biocidal products on the market.

Adopted by the SCCNFP during the 25th plenary meeting of 20 October 2003. SCCNFP/0690/03 Final. Opinion-Guidelines on the use of human volunteers in the testing of potentially cutaneous irritant cosmetic ingredients or mixtures of ingredients adopted by the plenary session of the SCCNFP of 25 November 1998. SCCNFP/0003/98 Final. Opinion concerning guidelines on the use of human volunteers in compatibility testing of finished cosmetic products – adopted by the Scientific Committee on Cosmetics and Non-food Products intended for consumers during the plenary session of 23 June 1999.

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Alternatives to Animal Testing by Michael Balls, Roy M. Harrison, Ronald E. Hester

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