By Nurullah Saracoglu (auth.), Mahmud Tareq Hassan Khan (eds.)

ISBN-10: 3540734058

ISBN-13: 9783540734055

N. Saracoglu: Functionalization of Indole and Pyrrole Cores through Michael style Additions.-

J. C. Menéndez: Chemistry of the Welwitindolinones.-

G. Topcu, O. Demirkiran: Lignans from Taxus Species.-

S. Süzen: Antioxidant actions of artificial Indole Derivatives and attainable task Mechanisms.-

M. González, H. Cerecetto, A. Monge: Quinoxaline 1,4-dioxide and Phenazine 5,10-dioxide Chemistry and Biology.-

M.T.H. Khan: Quinoline Analogues as Anti-angiogenic brokers and Telomerase Inhibitors

Y. Liu, S. Zhang, J.H. Jung, T. Xu: Bioactive Furanosesterterpenoids from Marine Sponge.-

C.A. Pujol, M.J. Carlucci, M.C. Matulewicz, E.B. Damonte: traditional Sulfated Polysaccharides for the Prevention and keep an eye on of Viral Infections.-

N. Hamdi, M. Saoud, A. Romerosa: 4-Hydroxy Coumarine: a flexible Reagent for the Synthesis of Heterocyclic and Vanillin Ether Coumarins with organic Activities.-

I. Orhan, B. Özcelik, B. Sener: present results of Antiviral and Antimicrobial evaluate of a few Heterocyclic Compounds from Turkish Plants

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Extra resources for Bioactive Heterocycles V

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The complex 114 was one of the most promising catalysts. The choice of acetonitrile as the solvent and A molecular sieves were also found to be advantageous. The 2the use of 4 ˚ acyl imidazole residue in the alkylation products of α,β-unsaturated 2-acyl imidazoles could be transformed into synthetically useful amides, esters, carboxylic acid, ketones, and aldehydes (Scheme 32) [105]. Moreover, the catalyst 114 produced both the intramolecular indole alkylation and the 2-substituted indoles in good yield and enantioselectivity (Scheme 33) [106].

The Michael addition product 130 was easily reduced to the optically active tryptamine 131 with lithium aluminum hydride and without racemization during the process. This process provides a valuable protocol for the production of potential biologically active, enantiomerically enriched tryptamine precursors [116]. Scheme 36 The supposed mechanism for Al(salen)Cl/amine catalyzed 1,4-addition involves a crucial stereocontrolled formation of an intermediate octahedral Schiff base–aluminum enolate 132 as depicted in Fig.

One-pot synthesis of homotryptamines 277a–k was achieved by the conjugate addition of indoles with acrolein in the presence of the MacMillan organocatalysts (118a, 274) followed by reductive amination (Scheme 60) [201]. Scheme 60 N-Michael addition of indole to achiral Ni(II) complex 278 led to the synthesis of racemic α-amino acid 280 [202]. The first of the two-step reactions is Functionalization of Indole and Pyrrole Cores via Michael-Type Additions 41 realized in the presence of NaH in acetonitrile.

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Bioactive Heterocycles V by Nurullah Saracoglu (auth.), Mahmud Tareq Hassan Khan (eds.)

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