By Kenneth D. Karlin, Shinobu Itoh, Steven Rokita

ISBN-10: 0470528354

ISBN-13: 9780470528358

Covers the greatly increasing topic of oxidative approaches mediated by means of copper ions inside of organic systems

Copper-mediated organic oxidations provide a vast diversity of essentially very important and in all probability sensible chemical tactics that move many chemical and pharmaceutical disciplines. This most modern quantity within the Wiley Series on Reactive Intermediates in Chemistry and Biology is split into 3 logical parts in the subject of copper/oxygen chemistry— organic platforms, thought, and bioinorganic types and applications—to discover the biosphere for its hugely advanced and therefore effective oxidative alterations within the discovery of recent sorts of interactions among molecular oxygen and copper ion. that includes a various number of material unified in a single entire and finished source, Copper-Oxygen Chemistry probes the basic elements of copper coordination chemistry, artificial natural chemistry, and organic chemistry to bare either the organic and chemical facets using the present fascinating learn efforts at the back of copper-oxygen chemistry. additionally, Copper-Oxygen Chemistry:

  • Addresses the considerably expanding literature on oxygen-atom insertion and carbon-carbon bond-forming reactions in addition to enantioselective oxidation chemistries

  • Progresses from organic structures to spectroscopy and thought, and onward to bioinorganic versions and applications

  • Covers a big selection of response varieties comparable to insertion and dehydrogenation reactions that make the most of the inexpensive, ample, and energy-containing O2 molecule

With thorough assurance by means of admired authors and researchers shaping techniques during this turning out to be box, this useful reference is key interpreting for bioinorganic chemists, in addition to natural, man made, and pharmaceutical chemists in academia and undefined.

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Soc. 2009, 131, 4657–4663. 57. ; Solomon, E. I. Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Reaction mechanism and role of the noncoupled nature of the active site J. Am. Chem. Soc. 2004, 126, 4991–5000. 58. Personal communication with Harry B. Gray. 59. Francisco, W. ; Smith, A. ; Merkler, D. ; Klinman, J. P. Investigation of the pathway for inter-copper electron transfer in peptidylglycine a-amidating monooxygenase J. Am. Chem.

Amzel, L. M. Amidation of bioactive peptides: The structure of peptidylglycine a-hydroxylating monooxygenase Science 1997, 278, 1300–1305. 26. Boswell, J. ; Reedy, B. ; Blackburn, N. J. Structural investigations on the coordination environment of the active-site copper centers of recombinant bifunctional peptidylglycine a-amidating enzyme Biochemistry 1996, 35, 12241–12250. 27. Reedy, B. ; Blackburn, N. J. Preparation and characterization of half-apo dopamineb-hydroxylase by selective removal of CuA.

An x-ray absorption study. J. Biol. Inorg. Chem. 2010, 15, 1195–1207. 30. Fitzpatrick, P. ; Villafranca, J. J. Mechanism-based inhibitors of dopamine betahydroxylase containing acetylenic or cyclopropyl groups J. Am. Chem. Soc. 1985, 107, 5022–5023. 31. Fitzpatrick, P. ; Flory, D. ; Villafranca, J. J. 3-Phenylpropenes as mechanism-based inhibitors of dopamine beta-hydroxylase: Evidence for a radical mechanism Biochemistry 1985, 24, 2108–2114. 32. Miller, S. ; Klinman, J. P. Secondary isotope effects and structure–reactivity correlations in the dopamine beta-monooxygenase reaction: Evidence for a chemical mechanism Biochemistry 1985, 24, 2114–2127.

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Copper-Oxygen Chemistry (Wiley Series of Reactive Intermediates in Chemistry and Biology) by Kenneth D. Karlin, Shinobu Itoh, Steven Rokita

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